Journal: Molecular Therapy Advances
Article Title: Gene therapy induces pigmentation in induced pluripotent stem cell-derived retinal pigment epithelium of OCA1A patients and albino rat eye
doi: 10.1016/j.omta.2026.201705
Figure Lengend Snippet: Suprachoroidal injection of AAV-hVMD:TYR in rat eye induces melanin pigment in retinal pigment epithelium and choroid (A) Fundus photograph of uninjected albino rat eye, with corresponding hematoxylin and eosin-stained histology section showing no pigment in RPE (arrowhead). (B) Fundus photograph of AAV-hVMD:TYR-injected albino rat eye, with corresponding hematoxylin and eosin-stained histology section showing pigment in RPE only (arrowhead). (C) Fundus photograph of AAV-hVMD:TYR-injected albino rat eye, with corresponding hematoxylin and eosin-stained histology section showing pigment in choroid (arrowhead). (D) Fontana-Masson-stained histology sections of uninjected pigmented rat (Long-Evans) eye, AAV-hVMD:GFP-injected albino rat eye and two AAV-hVMD:TYR-injected albino rat eye showing pigmentation in the RPE only (left) and RPE and choroid (right). Scale bars, 50 μm.
Article Snippet: Long-Evans and Sprague-Dawley (3–6 months old) were obtained from Charles river.
Techniques: Injection, Staining